Canine leukocyte antigen (DLA) class II genotypes related to continual enteropathy in French bulldogs and miniature dachshunds

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Vet Immunol Immunopathol. May 23, 2021; 237: 110271. doi: 10.1016 / j.vetimm.2021.110271. Online before printing.

ABSTRACT

Canine chronic enteropathy (CE) is a group of immunogenic disorders of unknown etiology characterized by chronic or recurrent gastrointestinal symptoms and inflammation. Diagnosing CE subtypes by response to treatment is a lengthy and difficult process, especially in refractory cases of the disease. Given the known association of the canine leukocyte antigen (DLA) class II genotype and various interracial and interracial immunogenetic disorders, this study was designed to explore the potential of determining susceptibility to refractory CE by identifying risk and protective genotypes in French Investigate bulldogs and miniature dachshunds. two popular breeds of dogs in Japan. The sequence-based genotyping of three DLA class II genes in 29 French bulldogs and 30 miniature dachshunds with refractory CE resulted in a protective haplotype DLA-DRB1 * 002: 01-DQA1 * 009: 01-DQB1 * 001: 01 against CE in French bulldogs (OR 0.09, 95% CI 0.01-0.71, p = 0.0084). No statistical difference was found between miniature dachshund cases and controls. These results, which differ widely from an earlier study of German Shepherds in the UK, were suggested as a possible indication of etiological differences in refractory CE between and within breeds and, more broadly, the potential for identifying such disease heterogeneity through DLA typing rated. The haplotype DLA-DQA1 / DQB1, which protects against CE in our French bulldogs, has been described as protective in various immune-mediated diseases such as Doberman’s hepatitis (Dyggve et al., 2011). Similarly, the DLA-DRB1 * 006: 01 risk allele for Doberman hepatitis was found in more French bulldogs with CE compared to controls, consistent with reports of genotypes associated with both risk and protection associated with various autoimmune diseases and races are divided. These results support an immunogenetic basis for the French Bulldog CE in our analysis and require further DLA studies with larger samples and different breeds for phenotypic clarification, which through epigenetic approaches and breeding can help with early detection, treatment and prophylaxis.

PMID: 34044267 | DOI: 10.1016 / j.vetimm.2021.110271

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